ALK mutants phosphorylate STAT3

Stable Identifier
R-HSA-9712085
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALK mutants phosphorylate STAT3
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STAT3 is tyrosine phosphorylated at residue 705, and this phosphorylation is required for STAT3 dimerization, nuclear translocation, and DNA binding. The function of serine 727 phosphorylation is not clear, however it occurs independently of tyrosine phosphorylation (reviewed in Yu et al, 2014; Guanizo et al, 2018).
Literature References
PubMed ID Title Journal Year
29873274 STAT3: a multifaceted oncoprotein

Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD

Growth Factors 2018
25342631 Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H

Nat. Rev. Cancer 2014
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Catalyst Activity

protein tyrosine kinase activity of STAT3-activating ALK mutants:STAT3 [cytosol]

Physical Entity
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2021-03-22)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2021-01-14)
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