STAT3 is tyrosine phosphorylated at residue 705, and this phosphorylation is required for STAT3 dimerization, nuclear translocation, and DNA binding. The function of serine 727 phosphorylation is not clear, however it occurs independently of tyrosine phosphorylation (reviewed in Yu et al, 2014; Guanizo et al, 2018).
Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD
Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H
protein tyrosine kinase activity of STAT3-activating ALK mutants:STAT3 [cytosol]
© 2022 Reactome
