PDE3B hydrolyses cAMP to AMP

Stable Identifier
R-HSA-9705507
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PDE3B hydrolyses cAMP to AMP
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Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3B inhibition promotes cardiac muscle contraction, a strategy used in heart failure.

Literature References
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Catalyst Activity

3',5'-cyclic-AMP phosphodiesterase activity of PDE3B [cytosol]

Physical Entity
PDE3B [cytosol] (Homo sapiens)
Activity
3',5'-cyclic-AMP phosphodiesterase activity (GO:0004115)
Orthologous Events
PDE3B hydrolyses cAMP to AMP (Bos taurus)
PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
PDE3B hydrolyses cAMP to AMP (Canis familiaris)
PDE3B hydrolyses cAMP to AMP (Danio rerio)
PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
PDE3B hydrolyses cAMP to AMP (Gallus gallus)
PDE3B hydrolyses cAMP to AMP (Mus musculus)
PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
PDE3B hydrolyses cAMP to AMP (Sus scrofa)
PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2018-11-23)
Reviewed
Varusai, TM  (2017-07-10)
Akkerman, JW  (2009-06-03)
Created
Jassal, B  (2020-10-26)
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