Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3B inhibition promotes cardiac muscle contraction, a strategy used in heart failure.
Maurice, DH
3',5'-cyclic-AMP phosphodiesterase activity of PDE3B [cytosol]
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