PDE3B hydrolyses cAMP to AMP

Stable Identifier
R-HSA-9705507
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PDE3B hydrolyses cAMP to AMP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3B inhibition promotes cardiac muscle contraction, a strategy used in heart failure.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
3',5'-cyclic-AMP phosphodiesterase activity of PDE3B [cytosol]
Physical Entity
PDE3B [cytosol]
Activity
3',5'-cyclic-AMP phosphodiesterase activity (0004115)
Orthologous Events
PDE3B hydrolyses cAMP to AMP (Bos taurus)
PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
PDE3B hydrolyses cAMP to AMP (Canis familiaris)
PDE3B hydrolyses cAMP to AMP (Danio rerio)
PDE3B hydrolyses cAMP to AMP (Gallus gallus)
PDE3B hydrolyses cAMP to AMP (Mus musculus)
PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
PDE3B hydrolyses cAMP to AMP (Sus scrofa)
PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
Authored
Jassal, B  (2018-11-23)
Reviewed
Akkerman, JW  (2009-06-03)
Varusai, TM  (2017-07-10)
Created
Jassal, B  (2020-10-26)
Cite Us!