GAB2 is presumed to be phosphorylated downstream of active FLT3 fusion proteins, but this has not been directly demonstrated. ETV6-FLT3 is unable to transform primary myeloid cells from the bone marrow of Gab2-/- mice, implicating signaling through this pathway (Chonabayashi et al, 2013).
Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A
protein tyrosine kinase activity of p-Y FLT3 fusions:GRB2:GAB2 [cytosol]
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