FLT3 fusions phosphorylate GAB2

Stable Identifier
R-HSA-9703438
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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FLT3 fusions phosphorylate GAB2
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GAB2 is presumed to be phosphorylated downstream of active FLT3 fusion proteins, but this has not been directly demonstrated. ETV6-FLT3 is unable to transform primary myeloid cells from the bone marrow of Gab2-/- mice, implicating signaling through this pathway (Chonabayashi et al, 2013).
Literature References
PubMed ID Title Journal Year
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A

Leukemia 2013
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y FLT3 fusions:GRB2:GAB2 [cytosol]

Physical Entity
p-Y FLT3 fusions:GRB2:GAB2 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-06)
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