ponatinib-resistant FLT3 mutants

Stable Identifier
R-HSA-9702614
Type
Pathway
Species
Homo sapiens
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Ponatinib is a first generation tyrosine kinase inhibitor with activity against a broad range of receptor tyrosine kinases, including FLT3 (reviewed Pemmeraju et al, 2014; Kazi and Roonstrand, 2019). This pathway describes FLT3 mutants that are resistant to inhibition by ponatinib.

Literature References
PubMed ID Title Journal Year
24749672 Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia

Pemmaraju, N, Kantarjian, H, Andreeff, M, Cortes, J, Ravandi, F

Expert Opin Investig Drugs 2014
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
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