ponatinib-resistant FLT3 mutants

Stable Identifier
R-HSA-9702614
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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ponatinib-resistant FLT3 mutants
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Ponatinib is a first generation tyrosine kinase inhibitor with activity against a broad range of receptor tyrosine kinases, including FLT3 (reviewed Pemmeraju et al, 2014; Kazi and Roonstrand, 2019). This pathway describes FLT3 mutants that are resistant to inhibition by ponatinib.

Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
24749672 Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia

Cortes, J, Kantarjian, H, Pemmaraju, N, Ravandi, F, Andreeff, M

Expert Opin Investig Drugs 2014
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-01)
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