Reactome | Active ALK phosphorylates JAK3

Active ALK phosphorylates JAK3

Stable Identifier

R-HSA-9701488

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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JAK3 is phosphorylated downstream of active ALK signaling (Zamo et al, 2002; Amin et al, 2003; Lai et al, 2005; Han et al, 2006a, b) Signaling through JAK3 and STAT3 contributes to cellular survival downstream of ALK signaling (Lai et al, 2005; Shi et al, 2006; reviewed in Palmer et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
12934099	Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma Ma, Y, Amin, HM, Rassidakis, GZ, Feretzaki, M, Leventaki, V, Medeiros, LJ, Lai, R, McDonnell, TJ, O'Connor, SL, Das, P	Oncogene	2003
19459784	Anaplastic lymphoma kinase: signalling in development and disease Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B	Biochem. J.	2009
11850821	Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death Chiarle, R, Piva, R, Inghirami, G, Levy, DE, Howes, J, Fan, Y, Chilosi, M, Zamo, A	Oncogene	2002
16939498	JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells Frantz, C, Amin, HM, Franko, B, Lai, R, Shi, X	Br. J. Haematol.	2006
16153455	Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma Amin, HM, Atwell, C, Rassidakis, GZ, Medeiros, LJ, Lin, Q, Lai, R	Hum. Pathol.	2005
16825495	Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma Frantz, C, Amin, HM, Franko, B, Han, Y, Lai, R, Shi, X	Blood	2006
16871283	Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma Amin, HM, Franko, B, Frantz, C, Han, Y, Lai, R, Lin, Q, Lee, J	Leukemia	2006