Active ALK phosphorylates SHC1

Stable Identifier
Reaction [transition]
Homo sapiens
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SHC1 is phosphorylated downstream of active ALK in a manner that depends on ALK kinase activity (Degoutin et al, 2007). SHC signaling downstream of the ALK receptor contributes to MAP kinase signaling and cellular proliferation and differentiation (Degoutin et al, 2007; Motegi et al, 2004; reviewed in Chiarle et al, 2008; Roskoski, 2013). The exact sites of SHC1 phosphorylation in the context of ALK signaling have not been explicitly demonstrated, but are presumed to be the canonical tyrosine phosphorylation sites of active SHC1 (reviewed in Ravichandran, 2001).

Literature References
PubMed ID Title Journal Year
15226403 ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

Kotani, M, Motegi, A, Sakuraba, H, Fujimoto, J, Yamamoto, T

J. Cell. Sci. 2004
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
11607835 Signaling via Shc family adapter proteins

Ravichandran, KS

Oncogene 2001
23201355 Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

Roskoski, R

Pharmacol. Res. 2013
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Vigny, M, Degoutin, J, Gouzi, JY

FEBS Lett. 2007
Catalyst Activity

protein tyrosine kinase activity of Active ALK dimer:SHC1 [plasma membrane]

Orthologous Events
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