Reactome | Active ALK phosphorylates SHC1

Active ALK phosphorylates SHC1

Stable Identifier

R-HSA-9700175

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SHC1 is phosphorylated downstream of active ALK in a manner that depends on ALK kinase activity (Degoutin et al, 2007). SHC signaling downstream of the ALK receptor contributes to MAP kinase signaling and cellular proliferation and differentiation (Degoutin et al, 2007; Motegi et al, 2004; reviewed in Turner and Alexander, 2006; Chiarle et al, 2008; Roskoski, 2013). The exact sites of SHC1 phosphorylation in the context of ALK signaling have not been explicitly demonstrated, but are presumed to be the canonical tyrosine phosphorylation sites of active SHC1 (reviewed in Ravichandran, 2001).

Literature References

PubMed ID	Title	Journal	Year
15226403	ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth Motegi, A, Fujimoto, J, Kotani, M, Sakuraba, H, Yamamoto, T	J. Cell. Sci.	2004
18097461	The anaplastic lymphoma kinase in the pathogenesis of cancer Chiarle, R, Voena, C, Ambrogio, C, Piva, R, Inghirami, G	Nat. Rev. Cancer	2008
16482213	Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells Turner, SD, Alexander, DR	Leukemia	2006
11607835	Signaling via Shc family adapter proteins Ravichandran, KS	Oncogene	2001
23201355	Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition Roskoski, R	Pharmacol. Res.	2013
17274988	ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation Degoutin, J, Vigny, M, Gouzi, JY	FEBS Lett.	2007