Active ALK phosphorylates PLCG1

Stable Identifier
R-HSA-9700171
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Active ALK phosphorylates PLCG1
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Based on studies with the NPM-ALK fusion, ALK is predicted to phosphorylate PLCG downstream of dimerization and autophosphorylation. PLCG signaling contributes to cellular proliferation downstream of ALK, and mutation of the ALK PLCG binding site eliminates the growth-factor independent transformation of Ba/F3 cells (Bai et al, 1998; reviewed in Chiarle et al, 2008; Palmer et al, 2009).
Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

Dieter, P, Morris, SW, Bai, RY, Duyster, J, Peschel, C

Mol. Cell. Biol. 1998
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of Active ALK:PLCG1 [plasma membrane]

Physical Entity
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK phosphorylates PLCG1 (Canis familiaris)
Active ALK phosphorylates PLCG1 (Danio rerio)
Active ALK phosphorylates PLCG1 (Gallus gallus)
Active ALK phosphorylates PLCG1 (Mus musculus)
Active ALK phosphorylates PLCG1 (Rattus norvegicus)
Active ALK phosphorylates PLCG1 (Sus scrofa)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-14)
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