Active ALK phosphorylates PLCG1

Stable Identifier
R-HSA-9700171
Type
Reaction
Species
Homo sapiens
Compartment
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Based on studies with the NPM-ALK fusion, ALK is predicted to phosphorylate PLCG downstream of dimerization and autophosphorylation. PLCG signaling contributes to cellular proliferation downstream of ALK, and mutation of the ALK PLCG binding site eliminates the growth-factor independent transformation of Ba/F3 cells (Bai et al, 1998; reviewed in Chiarle et al, 2008; Palmer et al, 2009).

Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

Dieter, P, Morris, SW, Bai, RY, Duyster, J, Peschel, C

Mol. Cell. Biol. 1998
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Active ALK:PLCG1 [plasma membrane]

Orthologous Events
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