Reactome | (PTN,MDK):PTPRZ oligomerizes

(PTN,MDK):PTPRZ oligomerizes

Stable Identifier

R-HSA-9700121

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PTN- and MDK-binding to the chondroitin sulphate moieties of PTPRZ promote oligomerization of the phosphatase, possibly by neutralizing the negative charge of the glycan group. Oligomerization of PTPRZ inactivates the enzyme, resulting in the accumulation of tyrosine-phosphorylated ALK and increased ALK-dependent signaling (Fukada et al, 2006; Kuboyama et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
16814777	Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization Fukada, M, Fujikawa, A, Chow, JP, Ikematsu, S, Sakuma, S, Noda, M	FEBS Lett.	2006
27445335	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION Kuboyama, K, Fujikawa, A, Suzuki, R, Tanga, N, Noda, M	J. Biol. Chem.	2016