(PTN,MDK):PTPRZ oligomerizes

Stable Identifier
R-HSA-9700121
Type
Reaction
Species
Homo sapiens
Compartment
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PTN- and MDK-binding to the chondroitin sulphate moieties of PTPRZ promote oligomerization of the phosphatase, possibly by neutralizing the negative charge of the glycan group. Oligomerization of PTPRZ inactivates the enzyme, resulting in the accumulation of tyrosine-phosphorylated ALK and increased ALK-dependent signaling (Fukada et al, 2006; Kuboyama et al, 2016).

Literature References
PubMed ID Title Journal Year
16814777 Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

Chow, JP, Fukada, M, Ikematsu, S, Sakuma, S, Fujikawa, A, Noda, M

FEBS Lett. 2006
27445335 Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION

Tanga, N, Kuboyama, K, Suzuki, R, Fujikawa, A, Noda, M

J. Biol. Chem. 2016
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