BCL2L11 (also known as BIM) is a pro-apoptotic factor whose expression is downregulated by FLT3 signaling as a consequence of AKT-dependent FOXO3 phosphorylation and nuclear export (Brandts et al, 2005; Scheijen et al, 2004; reviewed in Kazi and Ronnstrand, 2019; Yadav et al, 2018).. Downregulation of BCL2L11 may contribute to evasion of apoptosis and promote cellular survival downstream of FLT3 and FLT3 ITD signaling (Nordigarden et al, 2009).
Villunger, A, Lam, EW, Kraft, M, Jönsson, JI, Eliasson, P, Labi, V, Nordigården, A
Griffin, JD, Scheijen, B, Kang, H, Ngo, HT
Zhuang, L, Yadav, RK, Chauhan, AS, Gan, B
Berdel, WE, Serve, H, Rode, M, Brandts, CH, Sargin, B, Buerger, H, McMahon, M, Choudhary, C, Biermann, C, Lindtner, B, Müller-Tidow, C, Schwäble, J
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