FLT3 ITD- and STAT5-dependent CDKN1A gene expression

Stable Identifier
R-HSA-9698043
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FLT3 ITD- and STAT5-dependent CDKN1A gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STAT5 binding to its cognate sites at positions -692 and -684 of the CDKN1a promoter leads to FLT3-dependent CDKN1A expression (Takahashi et al, 2004).

Literature References
PubMed ID Title Journal Year
15003515 Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5

Licht, JD, Harigae, H, Takahashi, S, Kaku, M, Sasaki, T

Biochem. Biophys. Res. Commun. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
Active Unit
p-STAT5 [nucleoplasm]
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
Cite Us!