FLT3 ITD- and STAT5-dependent CDKN1A gene expression

Stable Identifier
R-HSA-9698043
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FLT3 ITD- and STAT5-dependent CDKN1A gene expression
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STAT5 binding to its cognate sites at positions -692 and -684 of the CDKN1a promoter leads to FLT3-dependent CDKN1A expression (Takahashi et al, 2004).
Literature References
PubMed ID Title Journal Year
15003515 Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5

Licht, JD, Harigae, H, Takahashi, S, Kaku, M, Sasaki, T

Biochem. Biophys. Res. Commun. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
Active Unit
p-STAT5 [nucleoplasm]
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
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