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CNRs bind CNR agonists
Stable Identifier
R-HSA-9696323
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
CNRs bind CNR agonists (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
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PPTX
|
SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol, the primary psychoactive component of cannabis (marijuana). It elicits its effects through weak partial agonist activity at cannabinoid-1 (CNR1, CB1) and cannabinoid-2 (CNR2, CB2) receptors and is used in the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who fail to respond adequately to conventional antiemetic treatments (Davis et al. 2007). Nabilone is an analogue of dronabinol and elicits its effects through weak partial agonist activity at CNR1 and CNR2 receptors. Nabilone is indicated for the treatment of the nausea and vomiting associated with cancer chemotherapy in patients who fail to respond adequately to conventional antiemetic treatments (Davis et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17139494
The emerging role of cannabinoid neuromodulators in symptom management
Maida, V
,
Pergolizzi, J
,
Davis, M
,
Daeninck, P
Support Care Cancer
2007
Participants
Input
CNR agonists [extracellular region]
CNRs [plasma membrane]
(Homo sapiens)
Output
CNRs:CNR agonists [plasma membrane]
(Homo sapiens)
Participates
as an event of
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Orthologous Events
CNRs bind CNR agonists (Bos taurus)
CNRs bind CNR agonists (Canis familiaris)
CNRs bind CNR agonists (Danio rerio)
CNRs bind CNR agonists (Gallus gallus)
CNRs bind CNR agonists (Mus musculus)
CNRs bind CNR agonists (Rattus norvegicus)
CNRs bind CNR agonists (Sus scrofa)
CNRs bind CNR agonists (Xenopus tropicalis)
Authored
Jassal, B (2021-03-25)
Reviewed
Huddart, R (2022-03-01)
Created
Jassal, B (2020-07-21)
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