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Protein M localizes to the Golgi membrane
Stable Identifier
R-HSA-9694555
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
,
endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of protein M (Homo sapiens)
Protein M localizes to the Golgi membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SARS-CoV-2 protein M accumulates in the Golgi complex and recruits Spike protein to the sites of virus assembly and budding in the ERGIC (Zhang et al, 2020).
Literature References
PubMed ID
Title
Journal
Year
33203855
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins
Zhang, J
,
Liu, Y
,
Liu, D
,
Teng, S
,
Cruz-Cosme, R
,
Wang, PH
,
Zhuang, MW
,
Tang, Q
Signal Transduct Target Ther
2020
Participants
Input
nascent M [endoplasmic reticulum lumen]
(Severe acute respiratory syndrome coronavirus 2)
Output
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Severe acute respiratory syndrome coronavirus 2)
Participates
as an event of
Maturation of protein M (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R (2020-08-28)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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