Maturation of protein M

Stable Identifier
R-HSA-9694594
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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Maturation of protein M
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This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Protein M, part of which is N-glycosylated, accumulates in the Golgi complex and recruits Spike protein to the sites of virus assembly and budding in the ERGIC (Voss et al, 2006; Voss et al, 2009)
Literature References
PubMed ID Title Journal Year
19534833 Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein

Voss, D, Pfefferle, S, Drosten, C, Stevermann, L, Traggiai, E, Lanzavecchia, A, Becker, S

Virol. J. 2009
16442106 Characterization of severe acute respiratory syndrome coronavirus membrane protein

Voss, D, Kern, A, Traggiai, E, Eickmann, M, Stadler, K, Lanzavecchia, A, Becker, S

FEBS Lett. 2006
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
viral protein processing (0019082)
Inferred From
Maturation of protein M (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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