E and N are recruited to the M lattice

Stable Identifier
R-HSA-9694444
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The ribonucleoprotein complex is recruited to the assembling virion through interactions with the M C-terminal tail, and appears to be independent of viral RNA (Hsieh et al, 2008; Hatakeyama et al, 2008; He et al, 2004; Luo et al, 2006; reviewed in Ujike and Taguchi, 2015). How much of this is fully conserved in SARS-COV-2 remains to be experimentally verified.

Literature References
PubMed ID Title Journal Year
15507643 Generation of synthetic severe acute respiratory syndrome coronavirus pseudoparticles: implications for assembly and vaccine production

Huang, Y, Yang, ZY, Kong, WP, Nabel, GJ

J. Virol. 2004
16254320 Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent

Hsieh, PK, Chang, SC, Huang, CC, Lee, TT, Hsiao, CW, Kou, YH, Chen, IY, Chang, CK, Huang, TH, Chang, MF

J. Virol. 2005
17530462 Coronavirus envelope protein: a small membrane protein with multiple functions

Liu, DX, Yuan, Q, Liao, Y

Cell. Mol. Life Sci. 2007
15147946 Assembly of human severe acute respiratory syndrome coronavirus-like particles

Ho, Y, Lin, PH, Liu, CY, Lee, SP, Chao, YC

Biochem. Biophys. Res. Commun. 2004
31133031 Coronavirus envelope protein: current knowledge

Schoeman, D, Fielding, BC

Virol. J. 2019
25855243 Incorporation of spike and membrane glycoproteins into coronavirus virions

Ujike, M, Taguchi, F

Viruses 2015
15351485 Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus

He, R, Leeson, A, Ballantine, M, Andonov, A, Baker, L, Dobie, F, Li, Y, Bastien, N, Feldmann, H, Strocher, U, Theriault, S, Cutts, T, Cao, J, Booth, TF, Plummer, FA, Tyler, S, Li, X

Virus Res. 2004
16684538 Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells

Yuan, Q, Liao, Y, Torres, J, Tam, JP, Liu, DX

FEBS Lett. 2006
16507314 Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein

Liao, Y, Yuan, Q, Torres, J, Tam, JP, Liu, DX

Virology 2006
15474033 Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system

Mortola, E, Roy, P

FEBS Lett. 2004
16343974 Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction

Luo, H, Wu, D, Shen, C, Chen, K, Shen, X, Jiang, H

Int. J. Biochem. Cell Biol. 2006
15713601 The transmembrane oligomers of coronavirus protein E

Torres, J, Wang, J, Parthasarathy, K, Liu, DX

Biophys. J. 2005
18703211 Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus

Hatakeyama, S, Matsuoka, Y, Ueshiba, H, Komatsu, N, Itoh, K, Shichijo, S, Kanai, T, Fukushi, M, Ishida, I, Kirikae, T, Sasazuki, T, Miyoshi-Akiyama, T

Virology 2008
18753196 The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles

Siu, YL, Teoh, KT, Lo, J, Chan, CM, Kien, F, Escriou, N, Tsao, SW, Nicholls, JM, Altmeyer, R, Peiris, JS, Bruzzone, R, Nal, B

J. Virol. 2008
18792806 Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus

Hsieh, YC, Li, HC, Chen, SC, Lo, SY

J. Biomed. Sci. 2008
16877062 The molecular biology of coronaviruses

Masters, PS

Adv. Virus Res. 2006
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
19322648 Expression and membrane integration of SARS-CoV E protein and its interaction with M protein

Chen, SC, Lo, SY, Ma, HC, Li, HC

Virus Genes 2009
Participants
Participates
Inferred From
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
Cite Us!