Reactome | RHOD binds effectors at the plasma membrane

RHOD binds effectors at the plasma membrane

Stable Identifier

R-HSA-9693198

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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RHOD binds effectors at the plasma membrane

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Active GTP bound RHOD binds to the following effectors at the plasma membrane:
DIAPH1 (Kyrkou et al. 2013)
PAK6 (Durkin et al. 2017)
PLXNA1 (Zanata et al. 2002)
PLXNB1 (Tong et al. 2007)

The following candidate RHOD effectors that can localize to plasma membrane and cytosol were reported in the high throughput screen by Bagci et al. 2020:
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DBN1 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

The following putative effectors do not bind to active RHOD:
ACTB (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
17916560	Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain Hota, PK, Park, HW, Tempel, W, Chugha, P, Alviani, RS, Shen, L, Buck, M, Li, M, Tong, Y	J Biol Chem	2007
22665057	RhoD participates in the regulation of cell-cycle progression and centrosome duplication Bai, M, Zerial, M, Ferguson, C, Hoffmann, I, Kyrkou, A, Soufi, M, Fotsis, T, Murphy, C, Bahtz, R, Parton, RG	Oncogene	2013
11784792	Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse Rohm, B, Hovatta, I, Zanata, SM, Püschel, AW	J Neurosci	2002
28486133	RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6 Leite, F, Valderrama, F, Arakawa, Y, Cordeiro, JV, Way, M, Handa, Y, Durkin, CH	Dev. Cell	2017
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020