RHOD binds effectors at the plasma membrane

Stable Identifier
R-HSA-9693198
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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RHOD binds effectors at the plasma membrane
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Active GTP bound RHOD binds to the following effectors at the plasma membrane:
DIAPH1 (Kyrkou et al. 2013)
PAK6 (Durkin et al. 2017)
PLXNA1 (Zanata et al. 2002)
PLXNB1 (Tong et al. 2007)

The following candidate RHOD effectors that can localize to plasma membrane and cytosol were reported in the high throughput screen by Bagci et al. 2020:
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DBN1 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

The following putative effectors do not bind to active RHOD:
ACTB (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
Literature References
PubMed ID Title Journal Year
17916560 Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain

Tong, Y, Chugha, P, Hota, PK, Alviani, RS, Li, M, Tempel, W, Shen, L, Park, HW, Buck, M

J Biol Chem 2007
22665057 RhoD participates in the regulation of cell-cycle progression and centrosome duplication

Kyrkou, A, Soufi, M, Bahtz, R, Ferguson, C, Bai, M, Parton, RG, Hoffmann, I, Zerial, M, Fotsis, T, Murphy, C

Oncogene 2013
11784792 Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse

Zanata, SM, Hovatta, I, Rohm, B, Püschel, AW

J Neurosci 2002
28486133 RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6

Durkin, CH, Leite, F, Cordeiro, JV, Handa, Y, Arakawa, Y, Valderrama, F, Way, M

Dev. Cell 2017
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
Participants
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Output
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Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Bisbal, M  (2021-02-20)
Created
Orlic-Milacic, M  (2020-06-30)
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