Reactome | VEGFA-165 dimer binds VEGFR2 dimer

VEGFA-165 dimer binds VEGFR2 dimer

Stable Identifier

R-HSA-9691215

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Binding of vascular endothelial growth factor A dimer (VEGFA dimer) to vascular endothelial growth factor receptor 2 dimer (VEGFR2, aka KDR, FLK1) (Ruch et al. 2007) induces receptor dimerization and autophosphorylation, leading to the recruitment of downstream signalling molecules. VEGFA isoform 4 (VEGFA-165) is widely expressed. Signaling through VEGFR2 is the major pathway that activates angiogenesis by inducing the proliferation, survival, sprouting and migration of endothelial cells (ECs), and also by increasing endothelial permeability (Lohela et al. 2009, Shibuya & Claesson-Welsh 2006, Claesson-Welsh & Welsh, 2013).

Literature References

PubMed ID	Title	Journal	Year
16336962	Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis Shibuya, M, Claesson-Welsh, L	Exp Cell Res	2006
19230644	VEGFs and receptors involved in angiogenesis versus lymphangiogenesis Lohela, M, Alitalo, K, Tammela, T, Bry, M	Curr. Opin. Cell Biol.	2009
17293873	Structure of a VEGF-VEGF receptor complex determined by electron microscopy Steinmetz, MO, Skiniotis, G, Walz, T, Ruch, C, Ballmer-Hofer, K	Nat. Struct. Mol. Biol.	2007
23216836	VEGFA and tumour angiogenesis Welsh, M, Claesson-Welsh, L	J. Intern. Med.	2013