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Calcineurin activates NFAT
Stable Identifier
R-HSA-2025928
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
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Signaling by the B cell receptor and the T cell receptor stimulate transcription by NFAT factors via calcium (reviewed in Gwack et al. 2007). Cytosolic calcium from intracellular stores and extracellular sources binds calmodulin and activates the protein phosphatase calcineurin. Activated calcineurin dephosphorylates NFATs in the cytosol, exposing nuclear localization sequences on the NFATs and causing the NFATs to be imported into the nucleus where they regulate transcription of target genes in complexes with other transcription factors such as AP-1 and JUN. Calcineurin in the target of the immunosuppressive drugs cyclosporin A and FK-506 (reviewed in Lee and Park 2006).
Literature References
PubMed ID
Title
Journal
Year
17572487
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes
Gwack, Y
,
Rao, A
,
Hogan, PG
,
Srikanth, S
,
Feske, S
Cell Calcium
2007
16951543
Regulation of NFAT activation: a potential therapeutic target for immunosuppression
Lee, M
,
Park, J
Mol Cells
2006
Participants
Events
Calcineurin binds NFATC1,2,3
(Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3
(Homo sapiens)
FKBP1A binds tacrolimus
(Homo sapiens)
Participates
as an event of
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Orthologous Events
Calcineurin activates NFAT (Bos taurus)
Calcineurin activates NFAT (Caenorhabditis elegans)
Calcineurin activates NFAT (Canis familiaris)
Calcineurin activates NFAT (Danio rerio)
Calcineurin activates NFAT (Dictyostelium discoideum)
Calcineurin activates NFAT (Drosophila melanogaster)
Calcineurin activates NFAT (Gallus gallus)
Calcineurin activates NFAT (Mus musculus)
Calcineurin activates NFAT (Rattus norvegicus)
Calcineurin activates NFAT (Saccharomyces cerevisiae)
Calcineurin activates NFAT (Schizosaccharomyces pombe)
Calcineurin activates NFAT (Sus scrofa)
Calcineurin activates NFAT (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000467
,
BIOMD0000000468
,
BIOMD0000000088
,
BIOMD0000000678
Authored
May, B (2011-12-11)
Reviewed
Wienands, J (2012-02-12)
Created
May, B (2011-12-20)
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