nsp9 forms a homodimer

Stable Identifier
R-HSA-9684282
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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nsp9 forms a homodimer
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Formation of the nsp9 dimer is necessary for viral viabilit. While the dimer retains only a slight advantage over the monomer in RNA binding the nsp9 monomer does not function in vivo, probably because of the correct positioning of RNA in the replication complex requiring a properly dimerized nsp9 (Miknis et al, 2009)0
Literature References
PubMed ID Title Journal Year
19153232 Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth

Donaldson, EF, Schultz, LW, Umland, TC, Rimmer, RA, Miknis, ZJ, Baric, RS

J. Virol. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-14)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Stephan, R  (2020-04-21)
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