Maturation of replicase proteins

Stable Identifier
R-HSA-9684325
Type
Pathway
Species
Homo sapiens
Related Species
Human SARS coronavirus
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Production of polyprotein fragments (so called replicase proteins) involves the repeated autocleavage of the polyprotein, liberating the two endopeptidases that finally cleave all fragments efficiently. Only nsp3 and nsp4 are post-translationally modified, they are glycosylated (Muramatsu et al, 2015; Harcourt et al, 2004; Oostra et al, 2007)

Literature References
PubMed ID Title Journal Year
27799534 SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

Muramatsu, T, Takemoto, C, Kim, YT, Wang, H, Nishii, W, Terada, T, Shirouzu, M, Yokoyama, S

Proc. Natl. Acad. Sci. U.S.A. 2016
17855519 Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication

Oostra, M, te Lintelo, EG, Deijs, M, Verheije, MH, Rottier, PJ, de Haan, CA

J. Virol. 2007
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Harcourt, BH, Jukneliene, D, Kanjanahaluethai, A, Bechill, J, Severson, KM, Smith, CM, Rota, PA, Baker, SC

J. Virol. 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
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