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mRNA9 is translated to Nucleoprotein
Stable Identifier
R-HSA-9683735
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
mRNA9 is translated to Nucleoprotein (Homo sapiens)
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Open reading frame 9a (ORF9a) of SARS-CoV-1 mRNA9 has a length of 1269 nt and encodes the 422 aa pre-nucleoprotein, the most abundant viral protein expressed during infection. Nucleoprotein is translated by cytosolic free ribosomes and most of it stays in the cytosol where it soon colocalizes with nsp3 and viral genomic RNA. It is involved in replication and transcription of the viral genome, but it is also a structural component of the virion (Thiel et al, 2003; Li et al, 2005; Stertz et al, 2007; Fung & Liu, 2019).
By mass spectrometric analysis, it was shown that methionine residues of the N protein are sulfur oxygenated (Krokhin et al. 2003), but the physiological relevance of this modification is unknown. The serine at position 2 of the N protein may be acetylated (Arnesen et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
16877062
The molecular biology of coronaviruses
Masters, PS
Adv. Virus Res.
2006
Participants
Input
m7G(5')pppAm-capped,polyadenylated-mRNA9 [cytosol]
(Human SARS coronavirus)
Output
N [cytosol]
(Human SARS coronavirus)
Participates
as an event of
Translation of Structural Proteins (Homo sapiens)
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Authored
Stephan, R (2020-04-08)
Reviewed
Acencio, ML (2020-05-27)
Mazein, A (2020-05-27)
Created
Stephan, R (2020-04-17)
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