mRNA9 is translated to Nucleoprotein

Stable Identifier
R-HSA-9683735
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Open reading frame 9a (ORF9a) of SARS-CoV-1 mRNA9 has a length of 1269 nt and encodes the 422 aa pre-nucleoprotein, the most abundant viral protein expressed during infection. Nucleoprotein is translated by cytosolic free ribosomes and most of it stays in the cytosol where it soon colocalizes with nsp3 and viral genomic RNA. It is involved in replication and transcription of the viral genome, but it is also a structural component of the virion (Thiel et al, 2003; Li et al, 2005; Stertz et al, 2007; Fung & Liu, 2019).

By mass spectrometric analysis, it was shown that methionine residues of the N protein are sulfur oxygenated (Krokhin et al. 2003), but the physiological relevance of this modification is unknown. The serine at position 2 of the N protein may be acetylated (Arnesen et al. 2005).

Literature References
PubMed ID Title Journal Year
16877062 The molecular biology of coronaviruses

Masters, PS

Adv. Virus Res. 2006
Participants
Participates
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
Cite Us!