Translation of Structural Proteins

Stable Identifier
R-HSA-9683701
Type
Pathway
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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SARS-CoV-1 mRNA is translated according to the ribosomal scanning model. Virus mRNA is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).

Literature References
PubMed ID Title Journal Year
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Participates
Event Information
Go Biological Process
Orthologous Events
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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Reviewed
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