Reactome | E protein gets palmitoylated

E protein gets palmitoylated

Stable Identifier

R-HSA-9683720

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human SARS coronavirus

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of protein E (Homo sapiens)
        
        E protein gets palmitoylated (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SARS-CoV E protein is modified by palmitoylation at all three cysteine residues. In general, palmitoylation is usually non-enzymatic (Liao et al, 2006, Veit, 2012).

Literature References

PubMed ID	Title	Journal	Year
22548323	Palmitoylation of virus proteins Veit, M	Biol. Cell	2012
16507314	Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein Liu, DX, Liao, Y, Tam, JP, Yuan, Q, Torres, J	Virology	2006

Participants

Input

Output

Participates

as an event of

Maturation of protein E (Homo sapiens)

Orthologous Events

E protein gets palmitoylated (Homo sapiens)

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Authored

Stephan, R (2020-04-08)

Created

Stephan, R (2020-04-17)

Cite Us!