Reactome | Spike protein gets palmitoylated

Spike protein gets palmitoylated

Stable Identifier

R-HSA-9683653

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human SARS coronavirus

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets palmitoylated (Homo sapiens)

General

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Two of the four cysteine-rich clusters of the SARS-CoV-1 spike protein are modified by palmitoylation. This is required for the protein's partitioning into detergent-resistant membranes and for cell–cell fusion. In general, palmitoylation is usually non-enzymatic (Petit et al, 2007; McBride and Machamer, 2010; Veit, 2012).

Literature References

PubMed ID	Title	Journal	Year
20580052	Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein Machamer, CE, McBride, CE	Virology	2010

Participants

Input

Output

Participates

as an event of

Maturation of spike protein (Homo sapiens)

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Authored

Stephan, R (2020-04-08)

Created

Stephan, R (2020-04-17)

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