nsp15 binds RB1

Stable Identifier
R-HSA-9682712
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
nsp15 binds RB1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Human SARS coronavirus 1 (SARS-CoV-1) non-structural protein 15 (nsp15) contains the LXCXE/D motif characteristic of proteins that bind to the retinoblastoma protein RB1. Binding to human RB1 increases the endonuclease activity of nsp15 but is not required for it. RB1 bound to nsp15 is retained in the cytosol. Interaction of nsp15 with RB1 likely affects the cell cycle of infected cells and probably modulates cytotoxicity of SARS-CoV-1 (Bhardwaj et al. 2012).
Literature References
PubMed ID Title Journal Year
22301153 The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein

Kao, CC, Liu, P, Bhardwaj, K, Leibowitz, JL

J. Virol. 2012
Participants
Input
Output
Participates
as an event of
Orthologous Events
nsp15 binds RB1 (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-13)
Cite Us!