nsp13 binds nsp12

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human SARS coronavirus
Locations in the PathwayBrowser
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nsp13, which functions as the viral helicase, is as a part of the human SARS coronavirus 1 (SARS-CoV-1) replication-transcription complex (RTC), where it is directly bound to nsp12, the viral RNA-dependent RNA polymerase. nsp12 increases the helicase activity of nsp13 (von Brunn et al. 2007, Adedeji et al. 2012, Jia et al. 2019).

Literature References
PubMed ID Title Journal Year
31131400 Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

Ren, Z, Wang, J, Jia, Z, Rao, Z, Lou, Z, Yan, L, Guo, J, Wu, L, Zheng, L, Zhang, L, Ming, Z

Nucleic Acids Res. 2019
17520018 Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome

Simpson, JC, Baric, R, von Brunn, A, Pepperkok, R, Teepe, C, Zimmer, R, Friedel, CC, Roberts, R, Haas, J

PLoS ONE 2007
22615777 Mechanism of nucleic acid unwinding by SARS-CoV helicase

Sarafianos, SG, Eoff, RL, te Velthuis, AJ, Adedeji, AO, Singh, K, Marchand, B, Snijder, EJ, Weiss, S

PLoS ONE 2012
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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