Replication transcription complex binds SARS-CoV-1 genomic RNA

Stable Identifier
R-HSA-9681314
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol, double membrane vesicle viral factory outer membrane
ReviewStatus
5/5
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Replication transcription complex binds SARS-CoV-1 genomic RNA
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The replication transcription complex (RTC) binds to the 3' end of the viral plus strand genomic RNA to initiate synthesis of the complementary minus strand. A 36 nucleotide sequence from the 3’-UTR of the plus strand, predicted to form a stable stem-loop structure, seems to be the minimal cis-acting RNA element required for the viral RNA-directed RNA polymerase (nsp12) to initiate RNA synthesis. The polyA tail also seems to play a role in the initiation of replication of viral genomic RNA (Ahn et al. 2012).
Literature References
PubMed ID Title Journal Year
22791111 Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates

Ahn, DG, Oh, JW, Choi, JK, Taylor, DR

Arch. Virol. 2012
Participants
Input
Output
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Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-01)
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