The antitussive drug dextromethorphan can elicit antidepressant-like actions at least in part through binding and stimulating the sigma non-opioid intracellular receptor 1 (SIGMAR1) (Lauterbach 2012, Fishback et al. 2010). Its endogenous ligand may be progesterone (Ganapathy et al. 1999). Small anecdotal studies suggest that ligands that target SIGMAR1 may be useful in treating central hypoventilation syndromes (Loiseau et al. 2018), suggesting a possible role for such drugs in treatment of COVID-19 symptoms.