SIGMAR1 binds dextromethorphan

Stable Identifier
Reaction [binding]
Homo sapiens
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The antitussive drug dextromethorphan can elicit antidepressant-like actions at least in part through binding and stimulating the sigma non-opioid intracellular receptor 1 (SIGMAR1) (Lauterbach 2012, Fishback et al. 2010). Its endogenous ligand may be progesterone (Ganapathy et al. 1999). Small anecdotal studies suggest that ligands that target SIGMAR1 may be useful in treating central hypoventilation syndromes (Loiseau et al. 2018), suggesting a possible role for such drugs in treatment of COVID-19 symptoms.

Literature References
PubMed ID Title Journal Year
22401777 An extension of hypotheses regarding rapid-acting, treatment-refractory, and conventional antidepressant activity of dextromethorphan and dextrorphan

Lauterbach, EC

Med. Hypotheses 2012
10087012 Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line

Ganapathy, ME, Prasad, PD, Huang, W, Seth, P, Leibach, FH, Ganapathy, V

J. Pharmacol. Exp. Ther. 1999
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