Reactome | CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1

CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1

Stable Identifier

R-HSA-9677585

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1

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Binding of the CSF3 (GCSF) dimer with the receptor CSF3R (GCSFR) causes dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton and Hall 2006) and signal transduction through JAK-STAT, RAS-RAF-ERK1,2, and PI3K. The CSF3 receptor, CSF3R, is constitutively associated with the kinases LYN (Corey et al. 1994) and JAK1 (Nicholson et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
7512720	Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation Nicholson, SE, Oates, AC, Harpur, AG, Ziemiecki, A, Wilks, AF, Layton, JE	Proc. Natl. Acad. Sci. U.S.A.	1994
8197119	Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases Corey, SJ, Burkhardt, AL, Bolen, JB, Geahlen, RL, Tkatch, LS, Tweardy, DJ	Proc. Natl. Acad. Sci. U.S.A.	1994
10537111	Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme Aritomi, M, Kunishima, N, Okamoto, T, Kuroki, R, Ota, Y, Morikawa, K	Nature	1999
16720384	The interaction of G-CSF with its receptor Layton, JE, Hall, NE	Front. Biosci.	2006
16492764	Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Tamada, T, Honjo, E, Maeda, Y, Okamoto, T, Ishibashi, M, Tokunaga, M, Kuroki, R	Proc. Natl. Acad. Sci. U.S.A.	2006