CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1

Stable Identifier
R-HSA-9677585
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of the CSF3 (GCSF) dimer with the receptor CSF3R (GCSFR) causes dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton and Hall 2006) and signal transduction through JAK-STAT, RAS-RAF-ERK1,2, and PI3K. The CSF3 receptor, CSF3R, is constitutively associated with the kinases LYN (Corey et al. 1994) and JAK1 (Nicholson et al. 1994).

Literature References
PubMed ID Title Journal Year
8197119 Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

Corey, SJ, Burkhardt, AL, Bolen, JB, Geahlen, RL, Tkatch, LS, Tweardy, DJ

Proc. Natl. Acad. Sci. U.S.A. 1994
7512720 Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation

Nicholson, SE, Oates, AC, Harpur, AG, Ziemiecki, A, Wilks, AF, Layton, JE

Proc. Natl. Acad. Sci. U.S.A. 1994
10537111 Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

Aritomi, M, Kunishima, N, Okamoto, T, Kuroki, R, Ota, Y, Morikawa, K

Nature 1999
16720384 The interaction of G-CSF with its receptor

Layton, JE, Hall, NE

Front. Biosci. 2006
16492764 Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex

Tamada, T, Honjo, E, Maeda, Y, Okamoto, T, Ishibashi, M, Tokunaga, M, Kuroki, R

Proc. Natl. Acad. Sci. U.S.A. 2006
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