Reactome | p-Y-STAT1,3,5 dimerize

p-Y-STAT1,3,5 dimerize

Stable Identifier

R-HSA-9674542

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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After being phosphorylated, STAT1, STAT3, and STAT5 (STAT5A and STAT5B) form homodimers (Tian et al. 1994, Tian et al. 1996, Ward et al. 1999, also inferred from mouse homologs). Phospho-STAT1 and phospho-STAT3 can also form heterodimers (Tian et al. 1994, Ward et al. 1999, also inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
7521688	Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor Tian, SS, Seidel, HM, Rosen, J, Stein, RB, Lamb, P	Blood	1994
9864153	Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration Schelen, AM, Smith, L, Ward, AC, Touw, IP, Hermans, MH, Antonissen, C, van Aesch, YM	Blood	1999
8977235	Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes Tian, SS, Rosen, J, Tapley, P, Stein, RB, Sincich, C, Lamb, P	Blood	1996