KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region

Stable Identifier
R-HSA-9667761
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region
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BK potassium channels (KCNMA1:KCNMB1) are complexed with LRRC52 in inner hair cells (IHCs) (inferred from mouse homologs), which renders the channels sensitive to voltage but insensitive to calcium ions (inferred from mouse homologs). In response to depolarization of the cell caused by opening of the mechanoelectrical transduction (MET) channel, KCNMA1:KCNMB1:LRRC52 channels located in the collar region of the IHC open and transport potassium ions out of the cell, thereby participating in the repolarization of the IHC (inferred from mouse homologs).

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Output
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as an event of
Catalyst Activity

voltage-gated potassium channel activity of KCNMA1:KCNMB1:LRRC52 [plasma membrane]

Physical Entity
KCNMA1:KCNMB1:LRRC52 [plasma membrane] (Homo sapiens)
Activity
voltage-gated potassium channel activity (GO:0005249)
Inferred From
Kcnma1:Kcnmb1:Lrrc52 transports potassium ions from the cytosol to the extracellular region (Mus musculus)
Cross References
Rhea
Authored
May, B  (2019-11-16)
Reviewed
Furness, DN  (2020-09-14)
Created
May, B  (2019-11-17)
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