Kcnma1:Kcnmb1:Lrrc52 transports potassium ions from the cytosol to the extracellular region

Stable Identifier
R-MMU-9667756
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Kcnma1:Kcnmb1:Lrrc52 transports potassium ions from the cytosol to the extracellular region

BK potassium channels (Kcnma1:Kcnmb1) are complexed with Lrrc52 in Inner Hair Cells (IHCs) (Lang et al. 2019, Lingle et al. 2019), which renders the channels sensitive to voltage but insensitive to calcium ions (Lang et al. 2019, Lingle et al. 2019). In response to depolarization of the cell caused by opening of the mechanoelectrical transduction (MET) channel, Kcnma1:Kcnmb1:Lrrc52 channels located in the collar region of the IHC open and transport potassium ions out of the cell, thereby participating in the repolarization of the IHC (Lang et al. 2019, Lingle et al. 2019.

Literature References
PubMed ID Title Journal Year
31348683 Expression of the LRRC52 γ subunit (γ2) may provide Ca2+-independent activation of BK currents in mouse inner hair cells

Lang, I, Jung, M, Niemeyer, BA, Ruth, P, Engel, J

FASEB J. 2019
31451634 LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells

Lingle, CJ, Martinez-Espinosa, PL, Yang-Hood, A, Boero, LE, Payne, S, Persic, D, V-Ghaffari, B, Xiao, M, Zhou, Y, Xia, XM, Pyott, SJ, Rutherford, MA

Proc. Natl. Acad. Sci. U.S.A. 2019
Participants
Input
Catalyst Activity

voltage-gated potassium channel activity of Kcnma1:Kcnmb1:Lrrc52 [plasma membrane]

Orthologous Events
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