Reactome | AVPR1A,B,2 bind atosiban

AVPR1A,B,2 bind atosiban

Stable Identifier

R-HSA-9667619

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Vasopressin-like receptors (Homo sapiens)
        
        AVPR1A,B,2 bind atosiban (Homo sapiens)

General

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Atosiban (trade names Tractocile, Antocin, Atosiban SUN) is a nonapeptide, desamino-oxytocin analogue, competitive vasopressin/oxytocin receptor antagonist used as a labour repressant (tocolytic) to halt premature labour. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane resulting in reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells as well as reduced influx of Ca2+ from the extracellular space through voltage-gated channels. In addition, atosiban suppresses oxytocin-mediated release of prostaglandins PGE and PGF from the decidua (Sanu & Lamont 2010, Kim et al. 2019). Atosiban antagonises uterine contractions and induces uterine quiescence. (Akerlund et al. 1985, Bossmar et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
4061066	The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin Akerlund, M, Carlsson, AM, Melin, P, Trojnar, J	Acta Obstet Gynecol Scand	1985
20463780	Critical appraisal and clinical utility of atosiban in the management of preterm labor Sanu, O, Lamont, RF	Ther Clin Risk Manag	2010
30962532	Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F_2α-induced Contractions and Inflammatory Responses in Human Myometrium Kim, SH, Riaposova, L, Ahmed, H, Pohl, O, Chollet, A, Gotteland, JP, Hanyaloglu, A, Bennett, PR, Terzidou, V	Sci Rep	2019
7802081	Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban Bossmar, T, Akerlund, M, Fantoni, G, Szamatowicz, J, Melin, P, Maggi, M	Am. J. Obstet. Gynecol.	1994