Reactome | Ub-p-PEX5 [peroxisomal membrane]

Ub-p-PEX5 [peroxisomal membrane]

Stable Identifier

R-HSA-9665183

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

Ub-p-Peroxisomal targeting signal 1 receptor, Ub-p-PEX5_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P50542 PEX5

Gene Names

PEX5, PXR1

Chain

chain:1-639

Reference Genes

BioGPS Gene:5830 PEX5

COSMIC (genes):PEX5 PEX5

CTD Gene:5830 PEX5

dbSNP Gene:5830 PEX5

ENSEMBL:ENSG00000139197 PEX5

ENSEMBL:ENSG00000288217 PEX5

HGNC:9719 PEX5

KEGG Gene (Homo sapiens):5830 PEX5

Monarch:5830 PEX5

NCBI Gene:5830 PEX5

OMIM:600414 PEX5

UCSC:P50542 PEX5

Reference Transcript

Other Identifiers

0002100369

11719618_a_at

11741493_a_at

16747770

203244_at

215481_s_at

2465572

2465576

3403300

3403301

3403302

3403303

3403305

3403306

3403307

3403309

3403310

3403311

3403316

3403317

3403319

3403321

3403322

3403323

3403324

3403325

3403326

3403327

3403328

3403329

3403330

3403332

40151_s_at

40152_r_at

5830

7953651

A_23_P48246

A_24_P372932

GE60411

GO:0000268

GO:0000425

GO:0003674

GO:0005052

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005777

GO:0005778

GO:0005782

GO:0005794

GO:0005829

GO:0006464

GO:0006605

GO:0006625

GO:0006810

GO:0006914

GO:0008022

GO:0008104

GO:0008150

GO:0009056

GO:0015031

GO:0016020

GO:0016558

GO:0016560

GO:0016561

GO:0016567

GO:0019899

GO:0022607

GO:0031267

GO:0031333

GO:0032991

GO:0033328

GO:0043226

GO:0045046

GO:0047485

GO:0051262

GO:0055085

GO:0065003

GO:0140311

HMNXSV003030185

HMNXSV003058153

Hs.158084.1.A1_3p_a_at

ILMN_1660232

PH_hs_0029792

TC12000109.hg

U35407_at

Z48054_at

g4506346_3p_at

Participates

as a component of

ATM:Ub-p-PEX5 [peroxisomal membrane] (Homo sapiens)

Other forms of this molecule

p-PEX5 [peroxisomal membrane]

PEX5 [peroxisomal membrane]

PEX5 [cytosol]

Inferred To

phospho-prx-5 [peroxisomal membrane] (Caenorhabditis elegans)

phospho-Pex5 [peroxisomal membrane] (Drosophila melanogaster)

phospho-Pex5 [peroxisomal membrane] (Mus musculus)

phospho-Pex5 [peroxisomal membrane] (Rattus norvegicus)

phospho-pex5 [peroxisomal membrane] (Danio rerio)

phospho-pex5 [peroxisomal membrane] (Dictyostelium discoideum)

phospho-pex5 [peroxisomal membrane] (Schizosaccharomyces pombe)

phospho-PEX5 [peroxisomal membrane] (Canis familiaris)

phospho-PEX5 [peroxisomal membrane] (Gallus gallus)

phospho-PEX5 [peroxisomal membrane] (Saccharomyces cerevisiae)

phospho-PEX5 [peroxisomal membrane] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 141

Coordinate

141

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (monoUb [cytosol]) at 209

Coordinate

209

Modification

monoUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001287718.1, XP_016875241.1, NP_001124498.1, XP_016875238.1, XP_016875242.1, NP_000310.2, XP_016875237.1, XP_016875243.1, NP_001124496.1, XP_011519100.1, XP_016875244.1, XP_011519101.1, NP_001124495.1, XP_011519102.1, XP_011519097.1, NP_001124497.1, XP_016875239.1, XP_011519099.1

OpenTargets

ENSG00000139197

HPA

ENSG00000139197-PEX5

GeneCards

P50542

Ensembl

ENSP00000266563, ENSP00000266564, ENSP00000407401, ENSP00000410159, ENST00000672776, ENST00000672541, ENST00000672694, ENST00000671993, ENSG00000139197, ENST00000672242, ENST00000434354, ENST00000455147, ENSP00000500509, ENSP00000499823, ENSP00000400647, ENST00000420616, ENST00000266563, ENSG00000288217, ENSP00000500043, ENSP00000500230, ENSP00000500696, ENST00000266564

PRO

P50542

Pharos - Targets

P50542

Orphanet

16646

PDB

3R9A, 2J9Q, 4BXU, 4KYO, 4KXK, 2W84, 2C0M, 1FCH, 2C0L

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.807	13
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.683	4
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.556	3
UniProt:EP400NL H9KV84			0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q49A88 CCD14			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:A8K3Q9 A8K3Q9			0.556	3
UniProt:Q8N5N8 Q8N5N8			0.556	3
UniProt:Q75MR5 Q75MR5			0.556	3
UniProt:Q6IPH7 Q6IPH7			0.556	3
UniProt:Q68DY9 ZNF772	1	ZNF772 [nucleoplasm] (R-HSA-3110231)	0.556	3
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:P06703 S10A6			0.556	3
UniProt:Q6IMN6 CAPR2			0.556	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2