Reactome | Ub-p-PEX5 [peroxisomal membrane]

Ub-p-PEX5 [peroxisomal membrane]

Stable Identifier

R-HSA-9665183

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

Ub-p-Peroxisomal targeting signal 1 receptor, Ub-p-PEX5_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P50542 PEX5

Gene Names

PEX5, PXR1

Chain

chain:1-639

Reference Genes

BioGPS Gene:5830 PEX5

COSMIC (genes):PEX5 PEX5

CTD Gene:5830 PEX5

dbSNP Gene:5830 PEX5

ENSEMBL:ENSG00000139197 PEX5

ENSEMBL:ENSG00000139197.11 PEX5

ENSEMBL:ENSG00000288217.3 PEX5

HGNC:9719 PEX5

KEGG Gene (Homo sapiens):5830 PEX5

Monarch:5830 PEX5

NCBI Gene:5830 PEX5

OMIM:600414 PEX5

UCSC:P50542 PEX5

Reference Transcript

Other Identifiers

0002100369

11719618_a_at

11741493_a_at

16747770

203244_PM_at

203244_at

215481_PM_s_at

215481_s_at

2465572

2465576

3403300

3403301

3403302

3403303

3403305

3403306

3403307

3403309

3403310

3403311

3403316

3403317

3403319

3403321

3403322

3403323

3403324

3403325

3403326

3403327

3403328

3403329

3403330

3403332

40151_s_at

40152_r_at

5830

7953651

A_23_P48246

A_24_P372932

GE60411

GO:0000038

GO:0000268

GO:0001764

GO:0005052

GO:0005515

GO:0005622

GO:0005737

GO:0005739

GO:0005777

GO:0005778

GO:0005782

GO:0005794

GO:0005829

GO:0006457

GO:0006625

GO:0006629

GO:0006635

GO:0006886

GO:0007005

GO:0007006

GO:0007029

GO:0007031

GO:0008022

GO:0015031

GO:0016020

GO:0016558

GO:0016560

GO:0016561

GO:0019899

GO:0021795

GO:0021895

GO:0030154

GO:0031267

GO:0031333

GO:0032991

GO:0033328

GO:0040018

GO:0043226

GO:0044183

GO:0044255

GO:0045046

GO:0047485

GO:0048468

GO:0048856

GO:0048870

GO:0050877

GO:0050905

GO:0055085

GO:0061024

GO:0065003

GO:0140311

GO:0140313

HMNXSV003030185

HMNXSV003058153

Hs.158084.1.A1_3p_a_at

ILMN_1660232

PH_hs_0029792

TC12000109.hg

U35407_at

Z48054_at

g4506346_3p_at

Participates

as a component of

ATM:Ub-p-PEX5 [peroxisomal membrane] (Homo sapiens)

Other forms of this molecule

p-PEX5 [peroxisomal membrane]

PEX5 [peroxisomal membrane]

PEX5 [cytosol]

Inferred To

phospho-Pex5 [peroxisomal membrane] (Drosophila melanogaster)

phospho-Pex5 [peroxisomal membrane] (Mus musculus)

phospho-Pex5 [peroxisomal membrane] (Rattus norvegicus)

phospho-pex5 [peroxisomal membrane] (Dictyostelium discoideum)

phospho-pex5 [peroxisomal membrane] (Schizosaccharomyces pombe)

phospho-pex5 [peroxisomal membrane] (Xenopus tropicalis)

phospho-PEX5 [peroxisomal membrane] (Bos taurus)

phospho-PEX5 [peroxisomal membrane] (Gallus gallus)

phospho-PEX5 [peroxisomal membrane] (Saccharomyces cerevisiae)

phospho-PEX5 [peroxisomal membrane] (Sus scrofa)

phospho-Ub-p-PEX5 [peroxisomal membrane] (Canis familiaris)

phospho-Ub-p-PEX5 [peroxisomal membrane] (Danio rerio)

Modified Residues

Name

O-phospho-L-serine at 141

Coordinate

141

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (monoUb [cytosol]) at 209

Coordinate

209

Modification

monoUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001124495.1, NP_001124497.1, XP_011519099.1, XP_011519097.1, XP_016875243.1, XP_016875239.1, XP_011519100.1, NP_001124498.1, XP_011519101.1, XP_016875242.1, NP_001287718.1, XP_016875238.1, NP_000310.2, XP_016875237.1, XP_016875241.1, NP_001124496.1, XP_011519102.1, XP_016875244.1

OpenTargets

ENSG00000139197

HPA

ENSG00000139197-PEX5

GeneCards

P50542

Ensembl

ENST00000266564, ENSP00000500696, ENSP00000500043, ENST00000266563, ENSG00000288217, ENSP00000410159, ENST00000675855, ENSP00000407401, ENSP00000266564, ENSP00000266563, ENST00000420616, ENST00000455147, ENSP00000499823, ENST00000671993, ENST00000672776, ENST00000672694, ENST00000672541, ENST00000672242, ENST00000434354, ENSG00000139197, ENSP00000500230, ENSP00000502374, ENSP00000400647, ENSP00000500509

PRO

P50542

Pharos - Targets

P50542

Orphanet

16646

HMDB Protein

HMDBP14577

PDB

4KYO, 1FCH, 2W84, 4BXU, 2J9Q, 3R9A, 4KXK, 2C0L, 2C0M

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.807	13
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.683	4
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.556	3
UniProt:EP400NL H9KV84			0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q49A88 CCD14			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:A8K3Q9 A8K3Q9			0.556	3
UniProt:Q8N5N8 Q8N5N8			0.556	3
UniProt:Q75MR5 Q75MR5			0.556	3
UniProt:Q6IPH7 Q6IPH7			0.556	3
UniProt:Q68DY9 ZNF772	1	ZNF772 [nucleoplasm] (R-HSA-3110231)	0.556	3
UniProt:P06703 S10A6			0.556	3
UniProt:Q6IMN6 CAPR2			0.556	3
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2