Reactome | Ub-p-PEX5 [peroxisomal membrane]

Ub-p-PEX5 [peroxisomal membrane]

Stable Identifier

R-HSA-9665183

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

Ub-p-Peroxisomal targeting signal 1 receptor, Ub-p-PEX5_HUMAN

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External Reference Information

External Reference

UniProt:P50542 PEX5

Gene Names

PEX5, PXR1

Chain

chain:1-639

Reference Genes

BioGPS Gene:5830 PEX5

COSMIC (genes):PEX5 PEX5

CTD Gene:5830 PEX5

dbSNP Gene:5830 PEX5

ENSEMBL:ENSG00000139197 PEX5

HGNC:9719 PEX5

KEGG:hsa:5830 PEX5

Monarch:5830 PEX5

NCBI Gene:5830 PEX5

OMIM:600414 PEX5

UCSC:P50542 PEX5

Reference Transcript

Participates

as a component of

ATM:Ub-p-PEX5 [peroxisomal membrane] (Homo sapiens)

Other forms of this molecule

PEX5 [cytosol]

PEX5 [peroxisomal membrane]

p-PEX5 [peroxisomal membrane]

Inferred To

phospho-Pex5 [peroxisomal membrane] (Drosophila melanogaster)

phospho-Pex5 [peroxisomal membrane] (Mus musculus)

phospho-Pex5 [peroxisomal membrane] (Rattus norvegicus)

phospho-pex5 [peroxisomal membrane] (Dictyostelium discoideum)

phospho-pex5 [peroxisomal membrane] (Schizosaccharomyces pombe)

phospho-PEX5 [peroxisomal membrane] (Bos taurus)

phospho-PEX5 [peroxisomal membrane] (Canis familiaris)

phospho-PEX5 [peroxisomal membrane] (Saccharomyces cerevisiae)

phospho-PEX5 [peroxisomal membrane] (Sus scrofa)

phospho-Ub-p-PEX5 [peroxisomal membrane] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 141

Coordinate

141

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (monoUb [cytosol]) at 209

Coordinate

209

Modification

monoUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_016875243.1, XP_016875244.1, NP_001338062.1, XP_047285223.1, XP_016875242.1, NP_001338061.1, NP_001338060.1, NP_001361577.1, NP_001338066.2, XP_047285218.1, XP_047285216.1, XP_016875241.1, XP_011519100.1, XP_011519102.1, XP_054188510.1, XP_011519101.1, NP_001338055.1, XP_011519097.1, NP_001338053.1, NP_001338059.1, NP_001338057.1, XP_054188509.1, XP_054188507.1, NP_001361576.1, XP_054188508.1, NP_001338056.1, NP_001361575.1, XP_016875238.1, XP_016875239.1, NP_001361574.1, NP_001124495.1, NP_001124497.1, NP_001338063.1, XP_047285221.1, XP_016875237.1, NP_001124498.1, NP_001124496.1, XP_054188515.1, XP_054188513.1, XP_011519099.1, NP_000310.2, NP_001287718.1, NP_001287718.2

OpenTargets

ENSG00000139197

ENSEMBL

ENST00000266564, ENST00000671993, ENST00000672242, ENST00000672694, ENST00000672776, ENSP00000500230, ENST00000672541, ENSP00000400647, ENSP00000500043, ENST00000434354, ENSG00000139197, ENST00000266563, ENST00000455147, ENST00000675855, ENSP00000407401, ENSP00000499823, ENSP00000500509, ENSP00000502374, ENSP00000266564, ENSP00000266563, ENST00000420616, ENSG00000288217, ENSP00000500696, ENSP00000410159

GeneCards

PEX5

HPA

ENSG00000139197-PEX5

PRO

P50542

Pharos - Targets

P50542

Orphanet

PEX5

HMDB Protein

HMDBP14577

PDB

4KYO, 4BXU, 4KXK, 2W84, 9GAG, 1FCH, 2C0L, 2J9Q, 3R9A, 7Z0K, 2C0M

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.807	13
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.683	4
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:Q6IMN6 CAPR2			0.556	3
UniProt:P06703 S10A6			0.556	3
UniProt:Q68DY9 ZNF772	1	ZNF772 [nucleoplasm] (R-HSA-3110231)	0.556	3
UniProt:Q6IPH7 Q6IPH7			0.556	3
UniProt:Q75MR5 Q75MR5			0.556	3
UniProt:Q8N5N8 Q8N5N8			0.556	3
UniProt:A8K3Q9 A8K3Q9			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:Q49A88 CCD14			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:EP400NL H9KV84			0.556	3
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.556	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2

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