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PolyUb-misfolded nascent CFTR [cytosol]
Stable Identifier
R-HSA-9665106
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
GFAP binds LAMP2a multimer (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
HSPA8:Substrate binds LAMP2a (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrate:LAMP2a binds HSP90 (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)
HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Late endosomal microautophagy (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Substrate translocates into late endosomal lumen (Homo sapiens)
PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Aggrephagy (Homo sapiens)
Aggresome dissociates from dynein and microtubule (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Dynein motors transport misfolded proteins (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol] (Homo sapiens)
Participants
components
misfolded CFTR [endoplasmic reticulum membrane]
(Homo sapiens)
Ub [cytosol]
(Homo sapiens)
Participates
as a member of
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Inferred To
Ub-misfolded nascent CFTR [cytosol]
(Bos taurus)
Ub-misfolded nascent CFTR [cytosol]
(Caenorhabditis elegans)
Ub-misfolded nascent CFTR [cytosol]
(Canis familiaris)
Ub-misfolded nascent CFTR [cytosol]
(Danio rerio)
Ub-misfolded nascent CFTR [cytosol]
(Dictyostelium discoideum)
Ub-misfolded nascent CFTR [cytosol]
(Drosophila melanogaster)
Ub-misfolded nascent CFTR [cytosol]
(Gallus gallus)
Ub-misfolded nascent CFTR [cytosol]
(Mus musculus)
Ub-misfolded nascent CFTR [cytosol]
(Plasmodium falciparum)
Ub-misfolded nascent CFTR [cytosol]
(Rattus norvegicus)
Ub-misfolded nascent CFTR [cytosol]
(Sus scrofa)
Ub-misfolded nascent CFTR [cytosol]
(Xenopus tropicalis)
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