ATM:PEX5 binds ATM

Stable Identifier
R-HSA-9664879
Type
Reaction
Species
Homo sapiens
Compartment
peroxisomal membrane
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ATM:PEX5 binds ATM
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After Peroxisomal targeting signal 1 receptor (PEX5) recruits Ataxia telangiectasia mutated protein (ATM) to the peroxisomal membrane, ATM is activated by the reactive oxygen species (ROS). ROS can oxidize and activate ATM by forming a disulphide cross-linked dimer at the Csy2991 residue (Guo Z et al. 2010).

Literature References
PubMed ID Title Journal Year
20966255 ATM activation by oxidative stress

Kozlov, S, Person, MD, Lavin, MF, Guo, Z, Paull, TT

Science 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ROS [cytosol]
Orthologous Events
ATM:PEX5 binds ATM (Caenorhabditis elegans)
ATM:PEX5 binds ATM (Canis familiaris)
ATM:PEX5 binds ATM (Danio rerio)
ATM:PEX5 binds ATM (Dictyostelium discoideum)
ATM:PEX5 binds ATM (Drosophila melanogaster)
ATM:PEX5 binds ATM (Gallus gallus)
ATM:PEX5 binds ATM (Mus musculus)
ATM:PEX5 binds ATM (Rattus norvegicus)
ATM:PEX5 binds ATM (Saccharomyces cerevisiae)
ATM:PEX5 binds ATM (Schizosaccharomyces pombe)
ATM:PEX5 binds ATM (Sus scrofa)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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