ATM:PEX5 binds ATM

Stable Identifier
R-HSA-9664879
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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After Peroxisomal targeting signal 1 receptor (PEX5) recruits Ataxia telangiectasia mutated protein (ATM) to the peroxisomal membrane, ATM is activated by the reactive oxygen species (ROS). ROS can oxidize and activate ATM by forming a disulphide cross-linked dimer at the Csy2991 residue (Guo Z et al. 2010).

Literature References
PubMed ID Title Journal Year
20966255 ATM activation by oxidative stress

Guo, Z, Kozlov, S, Lavin, MF, Person, MD, Paull, TT

Science 2010
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This event is regulated
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Created