After Peroxisomal targeting signal 1 receptor (PEX5) recruits Ataxia telangiectasia mutated protein (ATM) to the peroxisomal membrane, ATM is activated by the reactive oxygen species (ROS). ROS can oxidize and activate ATM by forming a disulphide cross-linked dimer at the Csy2991 residue (Guo Z et al. 2010).
Kozlov, S, Person, MD, Lavin, MF, Guo, Z, Paull, TT
© 2023 Reactome
