ATM binds PEX5

Stable Identifier
R-HSA-9664850
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The first step in pexophagy is the initiation by a signal that triggers downstream events to eventually degrade the peroxisome. Ataxia-telangiectasia mutated protein (ATM) is a serine/threonine protein kinase that is involve in DNA damage response. ATM is known to be involved in pexophagy (Katarzyna ZR et al. 2016). ATM binds with Peroxisomal targeting signal 1 receptor (PEX5) with the help of a SRL binding sequence in ATM (Zhang J et al. 2015).

Literature References
PubMed ID Title Journal Year
26344566 ATM functions at the peroxisome to induce pexophagy in response to ROS

Zhang, J, Tripathi, DN, Jing, J, Alexander, A, Kim, J, Powell, RT, Dere, R, Tait-Mulder, J, Lee, JH, Paull, TT, Pandita, RK, Charaka, VK, Pandita, TK, Kastan, MB, Walker, CL

Nat. Cell Biol. 2015
27068951 Autophagic degradation of peroxisomes in mammals

Zientara-Rytter, K, Subramani, S

Biochem. Soc. Trans. 2016
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