Leishmania parasite growth and survival

Stable Identifier
R-HSA-9664433
Type
Pathway
Species
Homo sapiens
Related Species
Leishmania major
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Leishmania parasites infecting macrophages are considered a good model to study successful evolutionary mechanisms of evasion of the macrophage mediated immune response (Olivier et al. 2005). To evade killing by the host, Leishmania parasites manipulate the host's cellular signaling mechanisms, to prevent the production of microbicidal molecules and stimulating the activation of protective signaling pathways or to interfere with effective antigen presentation (Liu et al. 2012a). In most natural infections or after the resolution of the disease, a few Leishmania parasites remain in the host, perhaps as a product of a balance between forces favouring parasite persistence and those favouring destruction (Mandell et al. 2017).

Literature References
PubMed ID Title Journal Year
22919674 The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response

Liu, D, Uzonna, JE

Front Cell Infect Microbiol 2012
28096392 Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts

Mandell, MA, Beverley, SM

Proc. Natl. Acad. Sci. U.S.A. 2017
Participants
Participates
Event Information
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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