Anti-inflammatory response favouring Leishmania parasite infection

Stable Identifier
R-HSA-9662851
Type
Pathway
Species
Homo sapiens
Related Species
Leishmania major
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Anti-inflammatory response favouring Leishmania parasite infection
Click the image above or here to open this pathway in the Pathway Browser

Macrophages specializing in tissue repair or associated with a Th2-type immune response are more permissive to infection with leishmania, since their defense mechanisms are not very efficient in eliminating the parasite and can contribute to its persistence (Lee et al. 2018).

Literature References
PubMed ID Title Journal Year
29247046 Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

Cope, FO, Romano, A, Ralph, DA, Chaves, MM, Paun, A, Lee, SH, Sacks, DL, Charmoy, M

J. Exp. Med. 2018
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
negative regulation of killing of cells of another organism (0051711)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Cross References
GlyCosmos
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-09-24)
Cite Us!