Anti-inflammatory response favouring Leishmania parasite infection

Stable Identifier
R-HSA-9662851
Type
Pathway
Species
Homo sapiens
Related Species
Leishmania major
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Macrophages specializing in tissue repair or associated with a Th2-type immune response are more permissive to infection with leishmania, since their defense mechanisms are not very efficient in eliminating the parasite and can contribute to its persistence (Lee et al. 2018).

Literature References
PubMed ID Title Journal Year
29247046 Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

Lee, SH, Charmoy, M, Romano, A, Paun, A, Chaves, MM, Cope, FO, Ralph, DA, Sacks, DL

J. Exp. Med. 2018
Participants
Participates
Event Information
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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