Reactome | Phosphorylation and activation of PLCG due to FCGR3A effect

Phosphorylation and activation of PLCG due to FCGR3A effect

Stable Identifier

R-HSA-9664278

Type

Reaction

Species

Homo sapiens

Related Species

Leishmania major

Compartment

plasma membrane, cytosol, extracellular region

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)

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Phosphorylation and activation of PLCG due to FCGR3A effect

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PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.

Literature References

PubMed ID	Title	Journal	Year
7517665	Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils Dusi, S, Donini, M, Della Bianca, V, Rossi, F	Biochem Biophys Res Commun	1994
8657103	Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk Chandran, KA, Law, CL, Clark, EA, Sidorenko, SP	Mol Cell Biol	1996
15161916	Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation Kim, YJ, Rhee, SG, Sekiya, F, Poulin, B	J Biol Chem	2004

Participants

Input

Output

Participates

as an event of

FCGR3A-mediated IL10 synthesis (Homo sapiens)

Catalyst Activity

protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]

Physical Entity

clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Homo sapiens)

Activity

protein tyrosine kinase activity (GO:0004713)

Disease

Name	Identifier	Synonyms
cutaneous leishmaniasis	DOID:9111	Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis

Authored

Murillo, JI (2020-02-05)

Reviewed

Gregory, DJ (2020-02-04)

Created

Murillo, JI (2019-10-22)

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