Phosphorylation and activation of PLCG due to FCGR3A effect

Stable Identifier
R-HSA-9664278
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
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PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Reviewed
Created