PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
Law, CL, Chandran, KA, Sidorenko, SP, Clark, EA
Dusi, S, Donini, M, Della Bianca, V, Rossi, F
Sekiya, F, Poulin, B, Kim, YJ, Rhee, SG
protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]
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