Release of PLCG from FCGR3A

Stable Identifier
R-HSA-9664271
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Release of PLCG from FCGR3A
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Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Jassal, B  (2020-01-07)
Murillo, JI  (2020-01-13)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
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