SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Stable Identifier
R-HSA-9661397
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The organic anion transporting polypeptide SLCO1B1 (OATP, OATP2, OATPC, SLC21A6), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (Konig et al. 2000, Cui et al. 2001).

Literature References
PubMed ID Title Journal Year
10644574 A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

Konig, J, Cui, Y, Nies, AT, Keppler, D

Am J Physiol Gastrointest Liver Physiol 2000
11134001 Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

Cui, Y, K├Ânig, J, Leier, I, Buchholz, U, Keppler, D

J. Biol. Chem. 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
sodium-independent organic anion transmembrane transporter activity of SLCO1B1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!