Reactome | SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Stable Identifier

R-HSA-9661397

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

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Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The organic anion transporting polypeptide SLCO1B1 (OATP, OATP2, OATPC, SLC21A6), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (Konig et al. 2000, Cui et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11134001	Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 Cui, Y, König, J, Leier, I, Buchholz, U, Keppler, D	J. Biol. Chem.	2001
10644574	A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Konig, J, Cui, Y, Nies, AT, Keppler, D	Am J Physiol Gastrointest Liver Physiol	2000