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S-GCC MRAS:GTP:SHOC2:PP1 mutants [plasma membrane]
Stable Identifier
R-HSA-9660507
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 mutants [plasma membrane] (Homo sapiens)
Participants
components
PPP1CB mutants [cytosol]
(Homo sapiens)
S-GCC MRAS:GTP [plasma membrane]
(Homo sapiens)
SHOC2 [cytosol]
(Homo sapiens)
Participates
as a candidate of
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
Noonan syndrome
DOID:3490
Turner's phenotype, karyotype normal (disorder)
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