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SHOC2 [cytosol]
Stable Identifier
R-HSA-9658444
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Leucine-rich repeat protein SHOC-2, SHOC2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
SHOC2 [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 mutants [plasma membrane] (Homo sapiens)
SHOC2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
SHOC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQ13 SHOC2
Gene Names
SHOC2, KIAA0862
Chain
chain:1-582
Reference Genes
BioGPS Gene:8036 SHOC2
COSMIC (genes):SHOC2 SHOC2
CTD Gene:8036 SHOC2
dbSNP Gene:8036 SHOC2
ENSEMBL:ENSG00000108061 SHOC2
HGNC:15454 SHOC2
KEGG:hsa:8036 SHOC2
Monarch:8036 SHOC2
NCBI Gene:8036 SHOC2
OMIM:602775 SHOC2
UCSC:Q9UQ13 SHOC2
Reference Transcript
RefSeq:XM_017016702.1 SHOC2
RefSeq:NM_001324336.1 SHOC2
RefSeq:NM_001324337.1 SHOC2
RefSeq:NM_001269039.2 SHOC2
RefSeq:XM_017016703.1 SHOC2
RefSeq:NM_007373.3 SHOC2
RefSeq:XM_017016704.1 SHOC2
Other Identifiers
11724482_x_at
11724483_s_at
16709223
16709239
16709242
202777_PM_at
202777_at
3264005
3264006
3264007
3264010
3264011
3264012
3264013
3264014
3264015
3264016
3264017
3264018
3264020
3264022
3264023
3264024
3264025
3264026
3264030
3264031
3264032
3264033
3264034
3264035
3264036
3264037
3264038
3264039
3264040
3264042
3264044
3264046
3264048
3264050
38659_at
43109_r_at
7930470
8036
A_14_P108938
A_14_P116638
A_19_P00801459
A_21_P0007078
A_23_P202565
GE53546
GE723777
GO:0000164
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0007165
GO:0007265
GO:0008157
GO:0008543
GO:0010976
GO:0019888
GO:0019903
GO:0038180
GO:0043226
GO:0045665
GO:0045666
GO:0046579
GO:0055085
GO:0071378
GO:0098772
GO:0140361
GO:2000178
HMNXSV003002948
HMNXSV003006193
ILMN_2158242
PH_hs_0005786
TC10000809.hg
TC10002288.hg
TC10002289.hg
g6677944_3p_at
p18209
Participates
as a component of
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 mutants [plasma membrane] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SHOC2 M173I [cytosol]
SHOC2 Q269_H270delinsHY [cytosol]
SHOC2 S2G [cytosol]
Inferred To
soc-2 [cytosol]
(Caenorhabditis elegans)
Shoc2 [cytosol]
(Mus musculus)
Shoc2 [cytosol]
(Rattus norvegicus)
shoc2 [cytosol]
(Danio rerio)
SHOC2 [cytosol]
(Bos taurus)
SHOC2 [cytosol]
(Gallus gallus)
SHOC2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016872191.1
,
NP_001255968.1
,
NP_001311265.1
,
NP_001311266.1
,
XP_016872192.1
,
XP_016872193.1
,
NP_031399.2
OpenTargets
ENSG00000108061
ENSEMBL
ENST00000689118
,
ENSP00000358464
,
ENSP00000510639
,
ENST00000685059
,
ENST00000689300
,
ENST00000369452
,
ENSP00000510210
,
ENSP00000510554
,
ENSP00000509273
,
ENSP00000509686
,
ENSP00000509754
,
ENST00000691441
,
ENSP00000265277
,
ENST00000265277
,
ENST00000688928
,
ENST00000691369
HPA
ENSG00000108061-SHOC2
PRO
Q9UQ13
Pharos - Targets
Q9UQ13
Orphanet
SHOC2
GlyGen
Q9UQ13
PDB
7SD0
,
7UPI
,
7T7A
,
7SD1
,
7TYG
,
7TXH
,
7TVF
,
7TVG
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96RT1 ERBIN
1
ERBIN [plasma membrane]
(R-HSA-1358718)
0.623
4
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.527
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.527
2
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