Reactome | SHOC2 [cytosol]

SHOC2 [cytosol]

Stable Identifier

R-HSA-9658444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucine-rich repeat protein SHOC-2, SHOC2_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by MRAS-complex mutants (Homo sapiens)
      - Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
        
        Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
        
        mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
        
        S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
        
        SHOC2 [cytosol] (Homo sapiens)
        
        S-GCC MRAS:GTP:SHOC2:PP1 mutants [plasma membrane] (Homo sapiens)
        
        SHOC2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQ13 SHOC2

Gene Names

SHOC2, KIAA0862

Chain

chain:1-582

Reference Genes

BioGPS Gene:8036 SHOC2

COSMIC (genes):SHOC2 SHOC2

CTD Gene:8036 SHOC2

dbSNP Gene:8036 SHOC2

ENSEMBL:ENSG00000108061 SHOC2

ENSEMBL:ENSG00000108061.13 SHOC2

HGNC:15454 SHOC2

KEGG Gene (Homo sapiens):8036 SHOC2

Monarch:8036 SHOC2

NCBI Gene:8036 SHOC2

OMIM:602775 SHOC2

UCSC:Q9UQ13 SHOC2

Reference Transcript

Other Identifiers

11724482_x_at

11724483_s_at

16709223

16709239

16709242

202777_PM_at

202777_at

3264005

3264006

3264010

3264011

3264012

3264013

3264014

3264022

3264030

3264031

3264032

3264033

3264034

3264035

3264038

3264039

3264040

3264042

3264044

3264046

3264048

3264050

38659_at

7930470

8036

A_14_P108938

A_14_P116638

A_19_P00801459

A_21_P0007078

A_23_P202565

GE53546

GO:0000164

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0007265

GO:0008157

GO:0008543

GO:0010976

GO:0019888

GO:0019903

GO:0023052

GO:0030154

GO:0038180

GO:0043226

GO:0045665

GO:0045666

GO:0046579

GO:0048856

GO:0071378

GO:0098772

GO:2000178

HMNXSV003002948

HMNXSV003006193

ILMN_2158242

PH_hs_0005786

TC10000809.hg

TC10002288.hg

TC10002289.hg

g6677944_3p_at

p18209

Participates

as a component of

Other forms of this molecule

SHOC2 S2G [cytosol]

SHOC2 Q269_H270delinsHY [cytosol]

SHOC2 M173I [cytosol]

Inferred To

soc-2 [cytosol] (Caenorhabditis elegans)

Shoc2 [cytosol] (Mus musculus)

Shoc2 [cytosol] (Rattus norvegicus)

shoc2 [cytosol] (Danio rerio)

SHOC2 [cytosol] (Bos taurus)

SHOC2 [cytosol] (Canis familiaris)

SHOC2 [cytosol] (Gallus gallus)

SHOC2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_031399.2, NP_001311265.1, XP_016872193.1, NP_001255968.1, NP_001311266.1, XP_016872192.1, XP_016872191.1

OpenTargets

ENSG00000108061

GeneCards

Q9UQ13

HPA

ENSG00000108061-SHOC2

Ensembl

ENSP00000358464, ENST00000689118, ENSP00000510210, ENSP00000265277, ENST00000689300, ENST00000685059, ENST00000691369, ENSG00000108061, ENSP00000510554, ENST00000369452, ENST00000265277, ENSP00000509686, ENSP00000510639, ENST00000691441, ENSP00000509754, ENST00000688928, ENSP00000509273

PRO

Q9UQ13

Pharos - Targets

Q9UQ13

Orphanet

18920

PDB

7TYG, 7TVF, 7TVG, 7SD0, 7T7A, 7TXH, 7SD1, 7UPI

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.623	4