RAS intrinsic GTPase activity hydrolyzes GTP to GDP

Stable Identifier
R-HSA-9649736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RAS proteins have weak intrinsic GTPase activity in the absence of other effectors (Gibbs et al, 1984; reviewed in Pylayeva-Gupta et al, 2011). Nucleotide attack is mediated by residue Q61 and facilitated by van der Waals bonds contributed by glycine residues at position 12 and 13; these three residues account for the majority of oncogenic and pathogenic mutations found in RAS proteins (reviewed in Prior et al, 2012). GAP proteins stimulate the intrinsic GTPase activity of RAS proteins by inserting an arginine residue into the active site, which contributes to proper positioning of the critical Q61 RAS residue (reviewed in King et al, 2013).

Literature References
PubMed ID Title Journal Year
23443682 Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

King, PD, Lubeck, BA, Lapinski, PE

Sci Signal 2013
21993244 RAS oncogenes: weaving a tumorigenic web

Pylayeva-Gupta, Y, Grabocka, E, Bar-Sagi, D

Nat. Rev. Cancer 2011
22589270 A comprehensive survey of Ras mutations in cancer

Prior, IA, Lewis, PD, Mattos, C

Cancer Res. 2012
6148751 Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

Gibbs, JB, Sigal, IS, Poe, M, Scolnick, EM

Proc. Natl. Acad. Sci. U.S.A. 1984
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of p21 RAS:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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