ERBB2 KD mutants bind trastuzumab

Stable Identifier
R-HSA-9649393
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region
ReviewStatus
5/5
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ERBB2 KD mutants bind trastuzumab
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The following ERBB2 KD mutants are at least partially sensitive to the therapeutic antibody trastuzumab (herceptin):

ERBB2 L755M (Nagano et al. 2018);
ERBB2 D769H (Nagano et al. 2018);
ERBB2 V777M (Nagano et al. 2018);
ERBB2 H878Y (Nagano et al. 2018);

Literature References
PubMed ID Title Journal Year
29967253 High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2

Kojima, S, Ueno, T, Iwase, H, Nagano, M, Kohsaka, S, Mano, H, Saka, K, Kawazu, M

Clin. Cancer Res. 2018
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-31)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2019-06-13)
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