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ERBB2 KD mutants bind trastuzumab
Stable Identifier
R-HSA-9649393
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants bind trastuzumab (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The following ERBB2 KD mutants are at least partially sensitive to the therapeutic antibody trastuzumab (herceptin):
ERBB2 L755M (Nagano et al. 2018);
ERBB2 D769H (Nagano et al. 2018);
ERBB2 V777M (Nagano et al. 2018);
ERBB2 H878Y (Nagano et al. 2018);
Literature References
PubMed ID
Title
Journal
Year
29967253
High-Throughput Functional Evaluation of Variants of Unknown Significance in
ERBB2
Kojima, S
,
Ueno, T
,
Iwase, H
,
Nagano, M
,
Kohsaka, S
,
Mano, H
,
Saka, K
,
Kawazu, M
Clin. Cancer Res.
2018
Participants
Input
ERBB2 KD mutants (trastuzumab sensitive):ERBIN:HSP90:CDC37 [plasma membrane]
(Homo sapiens)
trastuzumab [extracellular region]
Output
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Signaling by ERBB2 KD Mutants (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M (2019-07-31)
Reviewed
Kancha, RK (2019-09-16)
Created
Orlic-Milacic, M (2019-06-13)
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