Reactome | MANEA [Golgi membrane]

MANEA [Golgi membrane]

Stable Identifier

R-HSA-964729

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Glycoprotein endo-alpha-1,2-mannosidase, MANEA_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan trimming and elongation in the cis-Golgi (Homo sapiens)
        
        Alternative endo-mannosidase I route (Homo sapiens)
        
        MANEA [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5SRI9 MANEA

Gene Names

MANEA

Chain

chain:1-462

Reference Genes

BioGPS Gene:79694 MANEA

COSMIC (genes):MANEA MANEA

CTD Gene:79694 MANEA

dbSNP Gene:79694 MANEA

ENSEMBL:ENSG00000172469 MANEA

HGNC:21072 MANEA

KEGG:hsa:79694 MANEA

Monarch:79694 MANEA

NCBI Gene:79694 MANEA

OMIM:612327 MANEA

UCSC:Q5SRI9 MANEA

Reference Transcript

Other Identifiers

11725564_at

11725565_at

11725566_at

11745083_a_at

1554193_PM_s_at

1554193_s_at

1555227_PM_a_at

1555227_a_at

17011079

219003_PM_s_at

219003_s_at

222805_PM_at

222805_at

2917768

2917769

2917771

2917772

2917773

2917774

2917775

2917776

2917777

2917778

2917779

2917780

2917781

2917782

2917784

2917785

2917787

2917788

2917789

46370_at

53640_i_at

53642_r_at

69393_at

76638_at

79694

8121144

A_14_P128135

A_23_P255663

A_24_P187921

A_24_P69274

GE82889

GO:0000139

GO:0003824

GO:0004559

GO:0004569

GO:0005794

GO:0016020

GO:0016787

GO:0016798

GO:0043226

HMNXSV003035152

Hs.46903.0.S2_3p_at

Hs2.46903.2.S1_3p_s_at

Hs2.46903.3.S1_3p_s_at

ILMN_1699987

ILMN_1734702

ILMN_1757026

ILMN_2269092

PH_hs_0003334

TC06000817.hg

g13375878_3p_a_at

Inferred To

Manea [Golgi membrane] (Mus musculus)

Manea [Golgi membrane] (Rattus norvegicus)

MANEA [Golgi membrane] (Bos taurus)

MANEA [Golgi membrane] (Canis familiaris)

MANEA [Golgi membrane] (Gallus gallus)

MANEA [Golgi membrane] (Sus scrofa)

Dmel\CG14015 [Golgi membrane] (Drosophila melanogaster)

manea [Golgi membrane] (Danio rerio)

manea [Golgi membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000506887, ENST00000358812, ENSP00000507267, ENST00000682663, ENST00000684753, ENSP00000351669

OpenTargets

ENSG00000172469

IntEnz

3.2.1.130

HPA

ENSG00000172469-MANEA

PRO

Q5SRI9

Pharos - Targets

Q5SRI9

GlyGen

Q5SRI9

PDB

6ZFQ, 6ZJ5, 6ZDC, 6ZDK, 6ZDF, 6ZDL, 6ZFN, 6ZJ1, 6ZFA

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13061 TRDN	1	TRDN [sarcoplasmic reticulum lumen] (R-HSA-2855215)	0.527	2
UniProt:Q9UJ14 GGT7	2	GGT7(473-662) [plasma membrane] (R-HSA-1247919) GGT7(1-472) [plasma membrane] (R-HSA-1247890)	0.527	2
UniProt:Q96KN2 CNDP1			0.527	2
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.527	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.527	2
UniProt:Q9UKU6 TRHDE			0.527	2
UniProt:Q99784 NOE1			0.527	2
UniProt:Q16853 AOC3	1	AOC3 [plasma membrane] (R-HSA-5696151)	0.527	2

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