Reactome | AOC3 [plasma membrane]

AOC3 [plasma membrane]

Stable Identifier

R-HSA-5696151

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Membrane primary amine oxidase ecNumber1.4.3.21/ecNumber, AOC3_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - AOC3 deaminates BZAM (Homo sapiens)
      - AOC3 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
        
        AOC3 dimer [plasma membrane] (Homo sapiens)
        
        AOC3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16853 AOC3

Gene Names

AOC3, VAP1

Chain

chain:1-763

Reference Genes

BioGPS Gene:8639 AOC3

COSMIC (genes):AOC3 AOC3

CTD Gene:8639 AOC3

dbSNP Gene:8639 AOC3

ENSEMBL:ENSG00000131471 AOC3

HGNC:550 AOC3

Monarch:8639 AOC3

NCBI Gene:8639 AOC3

OMIM:603735 AOC3

UCSC:Q16853 AOC3

Reference Transcript

Other Identifiers

11725299_a_at

11725300_a_at

16834516

204894_PM_s_at

204894_s_at

33756_at

3722196

3722197

3722198

3722199

3722200

3722201

3722202

3722203

3722204

3722205

3722206

3722208

3722216

3722217

3722218

3722219

3722220

3722232

3722233

8007420

8007427

8639

A_14_P126213

A_23_P426305

GE62099

GO:0003824

GO:0005507

GO:0005509

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005783

GO:0005794

GO:0005886

GO:0005902

GO:0006954

GO:0007155

GO:0008131

GO:0009308

GO:0009986

GO:0016020

GO:0016491

GO:0016641

GO:0031410

GO:0042802

GO:0043226

GO:0046677

GO:0046872

GO:0046982

GO:0048038

GO:0052595

HMNXSV003016727

ILMN_1782086

PH_hs_0011676

TC17000540.hg

U39447_at

g6806883_3p_a_at

Participates

as a component of

AOC3 dimer [plasma membrane] (Homo sapiens)

Inferred To

Ghost homologue of AOC3 [plasma membrane] (Xenopus tropicalis)

LOC100520329 [plasma membrane] (Sus scrofa)

AOC3 [plasma membrane] (Bos taurus)

AOC3 [plasma membrane] (Canis familiaris)

AOC3 [plasma membrane] (Gallus gallus)

AOC3 [plasma membrane] (Mus musculus)

AOC3 [plasma membrane] (Rattus norvegicus)

Homologues of AOC3 [plasma membrane] (Bos taurus)

Homologues of AOC3 [plasma membrane] (Canis familiaris)

Homologues of AOC3 [plasma membrane] (Gallus gallus)

Homologues of AOC3 [plasma membrane] (Sus scrofa)

LOC110256000 [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2767

OpenTargets

ENSG00000131471

ENSEMBL

ENSP00000484312, ENSP00000477686, ENSP00000468632, ENST00000617500, ENST00000613571, ENSP00000312326, ENST00000591562, ENST00000308423

HPA

ENSG00000131471-AOC3

ZINC target

Q16853

PRO

Q16853

Pharos - Targets

Q16853

PDB

4BTY, 1US1, 2C11, 2C10, 1PU4, 2Y74, 4BTW, 3ALA, 2Y73, 4BTX

HMDB Protein

HMDBP00393

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q5SRI9 MANEA	1	MANEA [Golgi membrane] (R-HSA-964729)	0.527	2
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.527	2
UniProt:O75106 AOC2	1	AOC2 [plasma membrane] (R-HSA-5696150)	0.527	2
UniProt:Q9UBQ6 EXTL2	1	EXTL2 [endoplasmic reticulum membrane] (R-HSA-8953372)	0.527	2

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