SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol

Stable Identifier
R-HSA-9645220
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies
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Four members of the SLC16A gene family encode classical monocarboxylate transporters, MCT1-4. They all function as proton-dependent transporters of monocarboxylic acids such as lactate and pyruvate and ketone bodies such as acetacetate and beta-hydroxybutyrate. These processes are crucial in the regulation of energy metabolism and acid-base homeostasis.

SLC16A1 encodes MCT1, a ubiquitiously expressed protein (Garcia et al. 1994). Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT), resulting in an acidic intracellular environment and muscle degeneration (Merezhinskaya et al. 2000). Activating promotor mutations in SLC16A1 are associated with exercise-induced hyperinsulinism (EIHI), a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load (Otonkoski et al. 2000). MCT1 requires the binding of a single transmembrane glycoprotein (basigin, BSG) for activity (Halestrap 2013).

Literature References
PubMed ID Title Journal Year
24265240 Monocarboxylic acid transport

Halestrap, AP

Compr Physiol 2013
8124722 Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

Garcia, CK, Goldstein, JL, Pathak, RK, Anderson, RG, Brown, MS

Cell 1994
10590411 Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport

Merezhinskaya, N, Fishbein, WN, Davis, JI, Foellmer, JW

Muscle Nerve 2000
17701893 Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells

Otonkoski, T, Jiao, H, Kaminen-Ahola, N, Tapia-Paez, I, Ullah, MS, Parton, LE, Schuit, F, Quintens, R, Sipilä, I, Mayatepek, E, Meissner, T, Halestrap, AP, Rutter, GA, Kere, J

Am J Hum Genet 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monocarboxylic acid transmembrane transporter activity of SLC16A1:BSG [plasma membrane]
Physical Entity
Activity
Orthologous Events
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