Activator phosphorylates STAT5

Stable Identifier
R-HSA-9645137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription (STAT5A/STAT5B) is regulated by extracellular factors including cytokines and growth factors. Activators bind and phosphorylate STAT5 which results in its activation (Sarah C et al, 2013).

Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
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