esxA binds TLR2

Stable Identifier
R-HSA-9637638
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Mtb secreted Mtb 6 kDa early secretory antigenic target (esxA) binds to toll-like-receptor 2 (TLR2), inhibiting the human immune reponse (Pathak et al. 2007).

Literature References
PubMed ID Title Journal Year
17486091 Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages

Pathak, SK, Basu, S, Basu, KK, Banerjee, A, Pathak, S, Bhattacharyya, A, Kaisho, T, Kundu, M, Basu, J

Nat. Immunol. 2007
Participants
Participates
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
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