EsxA binds TLR2

Stable Identifier
R-HSA-9637638
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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EsxA binds TLR2
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Mtb secreted Mtb 6 kDa early secretory antigenic target (EsxA) binds to toll-like-receptor 2 (TLR2), inhibiting the human immune reponse (Pathak et al. 2007).
Literature References
PubMed ID Title Journal Year
17486091 Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages

Pathak, SK, Basu, S, Basu, KK, Banerjee, A, Pathak, S, Bhattacharyya, A, Kaisho, T, Kundu, M, Basu, J

Nat. Immunol. 2007
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Mondo
Authored
Stephan, R  (2019-02-19)
Reviewed
Deffur, A  (2019-10-23)
Wilkinson, RJ  (2019-10-23)
Created
Pardo, AM  (2019-02-19)
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